Cambridge life science start-up PredictImmune has received £4.3m to fund a study of its novel test for Crohn's disease. The Wellcome Trust is providing the cash to support a prospective multi-centre clinical trial of the prognostic biomarker test for treatment guidance in Crohn’s disease, which is one of the major forms of inflammatory bowel disease. The study is sponsored by Cambridge University Hospital NHS Foundation Trust and Cambridge University. The PredictImmune biomarker test was developed and validated in Crohn’s disease and ulcerative colitis patients by researchers at the university's department of medicine, part-funded by Wellcome. A simple whole blood test based on genetic markers, it enables for the first time and at first diagnosis of disease, prediction of which course a patient’s illness will take and, therefore, identification of patients likely to experience a severe, relapsing form of disease. Other studies have shown that patients who are … [Read more...] about Amazing new test could offer accurate diagnosis of Crohn’s disease
Diagnosis crohns disease
Two years ago, Catherine Maclaine’s life changed forever when she had “a bad bout of what we think was either gastric flu or gastroenteritis”. She recalls: “After the initial spell my stomach was never the same again. I was bloated, had stomach cramps and other symptoms, and was obviously very unwell. “I was told I had post-infectious irritable bowel syndrome and was put on the low FODMAP diet (the acronym stands for fermentable oligosaccharides, disaccharides, monosaccharides and polyols – a series of carbohydrates that can ferment in the colon to produce gas) and had to cut out things like wheat, dairy, onions and garlic. “It meant I was on a very restrictive diet, but rather than getting better my stomach just got worse.” Tests revealed Catherine was suffering from Crohn’s disease, an inflammatory bowel disorder that can lead to chronic abdominal pain, severe diarrhoea, fatigue, weight loss and even malnutrition, and often … [Read more...] about How a diagnosis of Crohn’s disease put lawyer Catherine Maclaine on a different career path
After seeing the toll that Crohn’s disease has taken on Dynamo, forcing the magician to put his career temporarily on hold, interest surrounding the incurable illness has surged, but what exactly is it? A form of Inflammatory Bowel Disease (IBD), Crohn’s is a chronic condition that causes inflammation in the digestive system, leaving sufferers with myriad symptoms that can severely inhibit their daily lives if not treated with the right medications. According to Crohn’s and Colitis UK, there are at least 300,000 Britons diagnosed with an IBD - another common form is Ulcerative Colitis - and while symptoms are treatable, there are currently no known cures. What are the symptoms? Symptoms vary but can include diarrhoea, extreme fatigue and severe pain. They usually begin in childhood or early adulthood, according to the NHS. In some cases, such as Dynamo’s, medications for Crohn’s can cause additional side effects, such as weight gain and arthritis. … [Read more...] about Crohn’s disease: What are the symptoms and is there a cure?
A MUM-OF-THREE has claimed she was dumped by her fiance after her battle with Chron's disease made her face swell like Dynamo's. Last week, Dynamo opened up about how his battle with the disease had caused his face to swell and significant weight gain due to his medication regime. His ordeal brought back painful memories for Vicki Grant, 37, whose face puffed up to almost double its normal size. She claims the condition resulted in her fiancé walking out on her and left her kids scared to look at her face. She told the Sunday Mirror: "Two months earlier he had proposed to me on a beach in Tenerife. But he could not deal with me having this. "He went out one night and never came back. He kissed me goodbye then broke up by text. "I felt scared and alone. I got to a point where I didn’t want to be alive, but I had three children. They were my strength." Vicki, from East London, suffered agonising stomach pains and mouth ulcers before she was given the diagnosis in 2013. She was … [Read more...] about Mum-of-three claims fiancé dumped her after Crohn’s disease made her face swell like Dynamo’s
Seeing Dynamo’s bloated face on his Twitter feed last week as he revealed his battle with Crohn’s disease brought back painful memories for Vicki Grant. The magician told how the steroids he takes to battle the inflammatory bowel condition made his body and face balloon. As a sufferer herself, Vicki knows only too well what it’s like to have the Crohn’s “moonface”. So in an act of support, the mum of four tweeted the star a picture of hers puffed up to almost double its usual size. “One of my sons told me ‘Mum, you scare me looking like that’,” says Vicki. “It broke my heart. I hated the way Crohn’s made me look. But when I saw Dynamo’s post it brought back memories. "It’s so great he’s not afraid to show everyone what the disease does.” Throughout her teenage years, Vicki, 37, suffered stomach pains and mouth ulcers – and it wasn’t until 2013 she was finally given a … [Read more...] about Mum dumped by fiancé after getting Dynamo ‘moonface’ due to Crohn’s disease