Artificial intelligence could help create more specific Alzheimer’s treatment BelfastTelegraph.co.uk Quicker more specific treatments for Alzheimer’s could be developed using advanced artificial intelligence, according to researchers at University College London (UCL). https://www.belfasttelegraph.co.uk/news/uk/artificial-intelligence-could-help-create-more-specific-alzheimers-treatment-37439486.html https://www.belfasttelegraph.co.uk/news/uk/article37439485.ece/fc2b4/AUTOCROP/h342/bpanews_771fa690-6774-499a-8869-f7fae10be381_1 Email Quicker more specific treatments for Alzheimer’s could be developed using advanced artificial intelligence, according to researchers at University College London (UCL). Medics have devised a new algorithm that can automatically spot different patterns of progression in patients suffering from a range of dementias, including Alzheimer’s disease. The algorithm, called Subtype and Stage Inference – or SuStaIn, uses … [Read more...] about Artificial intelligence could help create more specific Alzheimer’s treatment
Alzheimers disease treatment
Pharmaceutical companies AstraZeneca and Eli Lilly have decided to end the phase III trials of Lanabecestat, a drug meant to treat patients with Alzheimer's disease, after it was revealed it was unlikely to meet targets. An independent data monitoring committee came to the conclusion that the drug, which is an oral beta secretase cleaving enzyme (BACE) inhibitor, should stop trials as it was unlikely to meet endpoints upon completion of the trial period. Menelas Pangalos, executive vice-president of AstraZeneca's IMED biotech unit, said: “We are saddened by this outcome as our researchers are working tirelessly to find a solution for the many people who are impacted by this devastating disease.” “We are committed to ensuring our findings can be used to inform further research in the Alzheimer's community, given the importance of finding a treatment for this disease.” The committee's decision to stop trials was not based on safety concerns, unlike Johnson & … [Read more...] about AstraZeneca stops phase III trial for Alzheimer’s disease drug Lanabecestat
Scientists have developed a novel computational approach that incorporates individual patients' brain activity to calculate optimal, personalized brain stimulation treatment for Alzheimer's disease. Lazaro Sanchez-Rodriguez of the University of Calgary, Canada, and colleagues present their new framework in PLOS Computational Biology. Electrical stimulation of certain parts of the brain could help promote healthy activity in neural circuits impaired by Alzheimer's disease, a neurodegenerative condition. This experimental treatment has shown some promise in clinical trials. However, all patients currently receive identical treatment protocols, potentially leading to different outcomes according to individual variations in brain signaling. To investigate the possibility of personalized brain stimulation, Sanchez-Rodriguez and colleagues took a theoretical approach. They built a computational tool that incorporates patients' MRI scans and physiological brain signaling measurements to … [Read more...] about New Computational Tool could Help Optimize Treatment of Alzheimer’s Disease
DEMENTIA can be a devastating condition, for both the person suffering with it and their family and friends. In May 2018 it was confirmed EastEnders legend Barbara Windsor had been diagnosed with the degenerative brain disease. But what are the signs to look out for? What is Alzheimer’s disease? Alzheimer’s disease is named after the doctor who first described it in medical literature, Alois Alzheimer. The disease affects the brain, and more than 520,000 people in the UK are currently affected by the condition. A hallmark of the disease is the build-up of amyloid beta proteins in the brain, which causes plaques. The plaques then result in the loss of connections between nerve cells in the brain - and ultimately the death of those cells and a loss of brain tissue. Those with Alzheimer’s also have a shortage of key chemicals in the brain, which help transmit messages. A lack of these chemicals means the brain is unable to process certain messages how it would have … [Read more...] about What is Alzheimer’s disease, what are the causes, signs and symptoms of Barbara Windsor’s condition and how is it different to dementia?
Being diagnosed with Alzheimer’s disease is undoubtedly hard for the person suffering, but symptoms including memory loss, confusion and personality changes can also be incredibly difficult for their loved ones to cope with. Dame Barbara Windsor’s husband, Scott Mitchell, has revealed she sometimes forgets they are married, due to being diagnosed with Alzheimer’s in 2014. “She suddenly has no recollection of our history,” he told The Sun. In light of this, HuffPost UK spoke to six people with loved ones affected by the illness, to find out how they’ve coped with the challenges it brings, plus what advice they have for those who have recently had a diagnosis in the family. [READ MORE: What is Alzheimer’s disease? Symptoms, diagnosis and treatment explained] 1. Try to stay positive Chris King’s mum was diagnosed with Alzheimer’s in 2012 and at the time he didn’t realise “how much or how … [Read more...] about How To Cope When A Family Member Has Alzheimer’s Disease, From People Who’ve Been There